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KMID : 0367419930360101434
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Journal of Korean Pediatric Society
1993 Volume.36 No. 10 p.1434 ~ p.1440
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Plasma Immunoreactive Endothlin-1, Creatine Kinase and CK Isoenzyme and Its Relation to Neonate with Asphyxia
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Abstract
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Endotheline-1 (ET-1) is a potent vasoconstrictor peptide with 21 amino acid residues.
ET-1 is thought to have a key role in vasoconstriction, and cardiac, renal, and endocrine actions of the peptide.
Creatine Kinase(CK), also referred to as ATP-creatine-N-phosphotransferase, consists of either the B or M type. CK is found almost exclusively in muscle(MM), myocardium(MB), and brain(BB). It is to be an almost specific index of injury of
myocardium and
brain in hypoxic damage.
I measured the ET-1, CK isoenzyme in neonates among asphyxia group (14 cases), as a control devide into two group. 1st group(birth weight (2500 g, n=9) and 2nd group (body weight 2500g, n=11).
1) There was no significant difference between asphyxia and control 1st, 2nd group during postnatal 24 hrs include cord blood on irET-1(p< 0.05).
2) There was significant difference between asphyxia and control 1 st, 2nd group during postnatal 24 hrs include cord blood on CK and CK and CK isoenzyme (p<0.001).
3) There was significant difference between asphyxia and control 1st, 2nd group on CK-MB and CK-BB proportion (p< 0.001).
4) There was significant difference between cord blood and postnatal 24 hrs on total CK level (P< 0.001).
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